Thursday, November 28, 2019
8 Reasons Midterms are the Worst
Some people hate finals, but honestly, midterms are the worst. The majority of them dont even land in the middle of the term, start 3 weeks into the semester, and really only end right before finals. Need more convincing? Here are 8 reasons midterms are the worst: 1. It always sneak up on you. 2. Some professors think 1 midterm is not enough 3. Thatââ¬â¢s why some are before spring break. 4. And itââ¬â¢s awful because of all the midnight study snacks. 5. Some are right after spring break, but YOLO. 6. You immediately regret it when you return and have to go straight to the library. 7. Midterms arenââ¬â¢t on the same schedule, so the SQUAD is never together. 8. And you have no choice but to deal with it. Midterms suck, but itll be over before you know it. If you ever want to take a break and procrastinate, you can take one of our quizzes, or better yet, you can create your college profile!
Monday, November 25, 2019
Marilyn Manson essays
Marilyn Manson essays This band is a twist of Iggy Pop, KISS, and Alice Coopper. Starting in South Florida as a small industrial Goth band, Marilyn Manson has changed the mainstream music of today. They have come to be a leader and paved the way for other shock-rock bands. Just coming out with his fifth album this week, he will continue reaching out to rebellious teenagers that need some support. Marilyn Manson has been hitting charts because of their songs and lyrics, show performances, and public attention. One of the reasons why Marilyn Manson is famous today is because of their undefined musically talents. They are a five piece band which includes singer Marilyn Manson, lead guitarist Twiggy Ramirez, bassist John5, drummer Ginger Fish, and on keyboards M.W. Gacy. Each member has been playing music since childhood. Putting these musician's talents and creative minds together, they have accomplished more than most bands around. Unlike many artists today Manson with help from Ramarize writes and produces all songs that go onto their albums. Their lyrics are very skillfully written so that they will attract public attention and listeners. Manson gets lyrics from his personal thoughts and tragedies that happen to him. On their bands fourth album, he wrote about his girlfriends drug addiction in a song called Coma White, "A pill to make you numb, A pill to make you dumb, A pill to make you anybody else, But all the drugs in this world won't save her from herself." In this new album calle d Holywood, Manson was inspired by the violence he sees in entertainment and how it is affecting children and the world. Touring the world, visiting countries across the globe, and selling out concerts have been the role of Marilyn Manson since they became popular with the public in the mid-nineties. The band works hard to entertain their fans with new and outrageous performances. Most of their earnings from touring and album sales go into the performances and live sh...
Thursday, November 21, 2019
Business law Essay Example | Topics and Well Written Essays - 2000 words - 3
Business law - Essay Example After its establishment, Enron had adopted along with executed certain unethical accounting techniques with the specific objective of hiding its liabilities and other loses during the growth of its stock price. During this time, various experts of the US already provided warning to the company about its increasing debt, but Enron avoided this and moved on to the development of its business by making substantial investments. The financial collapse of Enron was a lesson for the other business houses prevailing in the US1. With this concern, the assignment focused on broadly discussing the unethical accounting practices conducted by Enron that made the company to face bankruptcy. The various responsibilities of the account practitioners in the company have been revealed in order to verify whether they are liable for leading the company towards facing bankruptcy or not. The prime objective of this paper is to determine that the conduct of unethical accounting practices had eventually mad e financial collapse of Enron. Case Background Enron had made a rapid growth since its formation. By the year 2001, it became the seventh biggest natural gas and electrical company in the entire region of the US. The scandal of Enron can be noticed for the reason of its increased level of earning business reputation and gaining substantial profits. After several years, Jeffery Skilling, the new CEO of the company appointed numerous skilled executives who were capable of hiding outstanding amounts that to be presented in the financial statements by using the methods of poor financial accounting. The company filed for bankruptcy in the year 2001 after experiencing a long-run loss in its business. It has been viewed that an increment in the annual revenue of the company was only US$ 9 to US$ 10 during the period of 1995 to 2000. This represents the loss that suffered by the company while conducting its business. It can also be viewed that the stock price of the company had a drastic fa ll from $90 per share to $1 from the middle of the year 2000 and lasted up to 2001 which created a great loss for the shareholders. After this incident, Enron checked its financial statement for the last five years and came to realize a total loss of $586 million2. Due to this heavy loss, Enron filled bankruptcy on December 2, 2001. It can be apparently observed that several problems faced by the company and its shareholders after the bankruptcy. In this regard, most of the employees of Enron were accused with charges and had been imprisoned. Enron lost a huge figure of customers due to bankruptcy and also for a case which was running in the US Supreme Court. The court ordered to pay back the customers with partial return. Being unable to overcome all these losses and negative reputation, Enron failed to restore its previous position in the market where it operates. In relation to the case of Enron, it can be affirmed that there were several reasons for which the company had experie nced bankruptcy. One of the major causes was the practice of unethical accounting practices that prevailed within the company. In this similar concern, the company adopted certain unplanned measures of financial reporting in order to hide the
Wednesday, November 20, 2019
International manegment Essay Example | Topics and Well Written Essays - 250 words
International manegment - Essay Example Silverlight Electronics in Korea has a different business operation approach from Cobalt. The two companies operate in different business and cultural environments. Therefore, negotiation has to address the conflict situation between the two companies. Secondly, the two companies have their potential power in business, which must be respected for a negotiation to be realized. Finally, the concept of options was addressed in the negotiation. Both companies have business options that may be utilized. Actually, I present new and better business options to Silverlight electronics by presenting my proposals to them. I have learned a lot from this negotiation. The most important learning is that all options in a negotiation have to be exhausted. By understanding the needs and expectations of the other company, I can present better business options to them and therefore, arrive at a negotiation more quickly. I will use this concept in my future negotiation with people and businesses
Monday, November 18, 2019
HRM analysis Research Paper Example | Topics and Well Written Essays - 2250 words
HRM analysis - Research Paper Example The hotel consists of more than 5000 rooms and suits for guests in four thirty storey towers, world class gourmet restaurants, 27000 square feet pool complex, Grand Spa, casino, clubs, etc. Different parts of the hotel have different themes, food courts, restraints, entertainment lounge etc. (Jay & Dwi, 2000). The hotel is set up on an area of 33 acres. MGM Grand Las Vegas most commonly offers accommodation services but in addition to this the hotel also serves as a venue for different shows, events and concerts. Moreover, MGM grand hotel incorporates pool parties, night clubs, shopping outlets, wedding chapel etc. History In the 60ââ¬â¢s a group of properties started as MGM Resorts International under Kirk Kerkorianââ¬â¢s leadership. After the grand opening of paradise hotel in early 1970s the second hotel was built in Las Vegas named MGM Grand Las Vegas. Both the hotels were the worldââ¬â¢s largest hotels at that time. MGM Grand Las Vegas was opened in 1993 for the first t ime. The hotel turned to be the largest hotel in the United States with over 5000 guest rooms. At the opening of MGM Grand the biggest intention was the creation of first hotel in Las Vegas that includes the Theme Park MGM Grand adventures behind casino. The objective behind this hotel was providing a friendly and family oriented atmosphere where all the family members could enjoy different activities except the casinos. Strategy A strategy that a company sets and adopts to achieve its desired business objectives and goals are known as business strategy. The strategies adopted by MGM Grand Las Vegas hotel are discussed ahead. Competitive strategies are associated with the business strategies in a way to develop a competitive edge for an organization. MGM Grand Las Vegas hotel has potential business strategies to predict the expectations of the customer most accurately and make them satisfied with creativity. Product differentiation is one of the most unique competitive strategies th at MGM Grand uses. One of the examples of this strategy is the introduction of M Life Payers Club in 2010. This club is basically a customer reward club where customers can earn points by shopping and using other services of the hotel and then use those points for other experiences like concerts, food etc. To compliment the services activities the hotel uses marketing and sales strategies (Alan, 2007). The unique communication platforms used by the hotel and the entertainment attractions has helped the hotel win a competitive advantage. The hotel uses strategies to stay ahead of competition. The various strategies adopted by MGM Grand have helped the hotel grow and expand to different countries. In 2006 MGM Grand Las Vegas focused on the extension of its brand into hotels subsidiary named MGM Hospitality. MGM hospitality is held responsible for the outsourcing of gaming and non-gaming both type of investments and the management opportunities. The opening of Grand Macau in China is a nother example of this. These investments helped in accumulating almost one billion dollars of capital in the same year. Market position The ability to establish a unique position in the mind of the customer by delivering benefits and unique features is known as the determinant for the organizations position in the market (Woods, Robert,
Friday, November 15, 2019
Effect Of Temperature On The Digestive Enzyme Pepsin Biology Essay
Effect Of Temperature On The Digestive Enzyme Pepsin Biology Essay In this study an experiment was carried out to determine if varied temperatures affect the rate at which enzymes function. Enzymes are biological catalysts; catalysts are substances that increase the rate of chemical reactions without being used up (BBC, 2010), without these catalysts it would take an extremely long time for these reactions to take place. The enzyme used in this particular experiment was pepsin; pepsin is a zymogen of pepsinogen. Pepsinogen is activated by hydrochloric acid, which is released from parietal cells in the stomach lining. The hormone gastrin and the vagus nerve trigger the release of both pepsinogen and hydrochloric acid from the stomach lining when food is ingested. Hydrochloric acid creates an acidic environment, which allows pepsinogen to unfold and cleave itself in an autocatalytic fashion, generating pepsin. (Life Science Network, 2010) A lot can be learnt about enzymes by studying the rate of enzyme catalyzed reactions, these rates of reaction can be studied in various ways. In this experiment, using a range of different temperatures, the enzyme pepsin will be mixed with egg albumen. This is high in protein and bound to the dye Coomassie blue to gain a light absorbance reading using a spectrophotometer and in effect see how much protein has been digested by the pepsin. Egg albumen was used as the protein source in this study as although it is composed mainly of around 80% water it has about 15% of its total mass made up from approximately 40 different types of proteins, mainly Ovalbumin (54%) (Edin Formatics, 1999). A spectrophotometer is a device used for measuring light intensity and will be used to determine the amount of protein in each mixture, it works by measuring the light intensity as a function of the colour or more specifically the wavelength of light (Global Water Instrumentation Inc, 2007) (Appendix 2). Therefore the lower the reading means less light has been absorbed by the solution being tested indicating in this case that more protein (egg albumen) has been digested by the enzyme (pepsin) and the lower the reading the faster the enzyme reaction rate. If enzyme reactions are affected by temperature, then changes in temperature may bring about different absorbances of light readings related to how much protein has been broken down by the enzyme. As pepsin is found in the stomach it would seem only logical to assume the optimum temperature for this particular enzyme would be around 37Ã °c, human body temperature. Method A cuvette was filled with 0.5ml of distilled water and placed in a spectrophotometer, then the machine was calibrated by pressing the zero button with the spectrophotometer set to a wavelength of 595nm. After calibration 0.5ml of egg albumen (2mg.cm-Ã ³) was added to a test tube using a glass pipette and incubated in a pre heated water bath at a temperature of 10Ã °c (then 20Ã °c, 30Ã °c, 40Ã °c, 50Ã °c, 60Ã °c, 70Ã °c) for five minutes. 0.5ml of pepsin (0.1%) was then added to the test tube and incubated at the same temperature for a further ten minutes. After this incubation period 2.0ml of Coomassie blue reagent was added to the test tube and immediately mixed by capping the test tube with parafilm and inverting several times. After the test tubes contents had been mixed they were carefully poured into a cuvette and placed into the spectrophotometer with the light absorbance levels being recorded at a wavelength of 595nm. The experiment was carried out three times at each temperature to achieve reliable data. Results The results documented in Table 1 are the light absorbance reading averages of three separate experiments carried out at each temperature. A full set of results can be seen in Appendix 1. Figure 1 shows the averaged results plotted on a scatter graph. Table 1 Temperature (Degrees Celsius) Average light absorbance at 595nm 10 2.501 20 2.550 30 2.516 40 2.403 50 2.543 60 2.740 70 2.806 Fig 1 Change absorbance Discussion The results in Table 1 as well as the bell curve graph (Fig 1) show that the optimum temperature as predicted in the hypothesis seems to be 40Ã °c, close to human body temperature. These results also show that temperature has a definite effect on the rate the enzyme reacts to breakdown the protein in the egg albumen. Table 1 shows that at 10Ã °c, 20Ã °c and 30Ã °c the light absorbed by the solution is more than at 40Ã °c, this is because the pepsin has not broken down as much of the egg albumen at lower temperatures as it has at 40Ã °c so the spectrophotometer is picking up more undigested protein particles in these readouts. The same applies to the temperatures above 40Ã °c and indicates 40Ã °c is the best temperature range for pepsin to be active. Enzymes are made up of amino acids; amino acids are the basic building blocks of proteins consisting of a basic amino group, a carboxyl group, a hydrogen atom and an organic side group attached to the carbon atom (Biology Online, 2010). When an enzyme is formed it is made by stringing together between 100 to 1,000 amino acids in a specific and unique order defining the three dimensional shape of the enzyme and its particular chemical reactivity (Brain, M. 2000). The lock and key theory explains how an enzyme may work, it utilizes the concept of an active site on the enzyme. The theory is that a particular part of the enzymes surface has a strong affinity to the substrate (protein). The substrate is held in such a way that its conversion to the reaction products is more favorable. If you consider the enzyme is the lock and the substrate is the key, the key is inserted in the lock and turns it to open the door letting the reaction proceed (Worthington Biochemical Corporation, 2010) (Appendix 3). However, the induced fit theory expands on the rigid lock and key theory. This updated view of enzymology proposes that the substrate causes a conformational change in the enzyme so the active site achieves the exact configuration for a reaction to occur, the overall effect being a tighter binding between the enzyme and substrate (Allaby, M. 1999) (Appendix 4). The benefit of this tighter binding would be a faster reaction rate as more surface area of the enzyme would be in contact with the substrate. The kinetic collision theory describes temperature affects on a system as the amount of kinetic energy it has, a lower temperature will provide less kinetic energy than a higher temperature. When molecules collide the kinetic energy can be converted into chemical potential energy, if the chemical potential is great enough the activation energy or energy required for an enzyme to work can be reached. The more chemical potential energy molecules have when they collide, a greater number of molecules per unit time will reach the activation energy needed to bind the enzymes active site to the protein resulting in a quicker rate of reaction. If the temperature gets too high some of the weak bonds that determine the shape of a protein and its active site could be broken resulting in the enzyme becoming denatured and decreasing the rate of reaction sometimes rendering the enzyme inactive (Brooklyn College, 2010). Figure 1 shows that after 50Ã °c the enzyme reaction rate slows down considera bly, the enzyme is denaturising at a faster rate than it is below 30Ã °c. This change in enzyme reaction rate may be due to the fact that pepsins are stored at low temperatures to prevent the enzyme destroying itself, therefore pepsin is less active at lower temperatures until it reaches its activation energy around 30Ã °c and anything beyond around 50Ã °c 55Ã °c will rapidly denature the pepsin so the molecules in the active site can no longer bind to the protein and produce a reaction, rendering the enzyme inactive permanently. Once the pepsin has digested the egg albumen it would still be difficult to analyse the amount of protein left at each temperature, this is why Coomassie was added before taking a reading. In an acidic environment the protein will bind to Coomassie causing a spectral shift from a reddish/brown colour with a low absorbance maximum of 465nm to a light blue colour with a higher maximum absorbance of 610nm with the difference of the two colours greatest at 595nm, an optimal wavelength (Thermo Fisher Scientific, 2010). The binding of the Coomassie takes place when the red form donates its free electron to the ionisable groups on the protein causing a disruption of the proteins normal state and revealing its hydrophobic pockets. These pockets, via Van der Waals forces (attractive and repulsive forces between molecules) bind to the non polar region of the dye, putting the positive amine groups close to the negative charge of the dye, creating a strong bond. Binding of the protein stabilizes the blue form of Coomassie dye, thus the amount of complex present in solution is a measure for the protein concentration by use of an absorbance reading. (Bradford M, 1976, P248-254) Although this experiment has produced reliable accurate data that has proven the hypothesis right, many things could affect the results and readings obtained. When using such an accurate way of recording the data such as a spectrophotometer a number of things could affect the reliability of the results. Things like minor differences in volumes of substances added to the test tubes or inattentive timing methods could be damaging to the results obtained. Simple human error could possibly influence any results with any fingerprints or water on the cuvette affecting the absorbance readings. Conclusion In conclusion, the study carried out was adequate for the data required and indicated that temperature definitely affects the rate at which an enzyme reacts. As long as the method is executed well this is a great experiment to look at temperature and its effect on enzyme activity however as with any scientific study human input is a crucial factor and could affect the quality of results. Another experiment may need to be carried out to determine what the optimum temperature is on a more specific scale, something closer to body temperature would help to discover a more precise optimum temperature, 35Ã °c 40Ã °c for example. As well as finding out an exact optimum temperature a further study to find out the optimum pH of pepsin could be done to further enhance the enzymes rate of reaction, focused around the acidic pH in the human stomach. Appendices Appendix 1 Temperature (Ã °c) Absorbance at 595nm (Reading 1) Absorbance at 595nm (Reading 2) Absorbance at 595nm (Reading 3) 10 2.430 2.550 2.520 20 2.480 2.530 2.640 30 2.500 2.510 2.540 40 2.360 2.400 2.450 50 2.520 2.560 2.550 60 2.660 2.780 2.780 70 2.800 2.820 2.800 Appendix 2 http://commons.wikimedia.org/wiki/File:Spetrophotometer-en.svg Appendix 3 http://www.chemistry.wustl.edu/~edudev/LabTutorials/Carboxypeptidase/images/lockkey.jpg Appendix 4 http://wpcontent.answers.com/wikipedia/commons/thumb/2/24/Induced_fit_diagram.svg/450px-Induced_fit_diagram.svg.png
Wednesday, November 13, 2019
Order Out of Chaos Essay -- History, Roman Empire, Charlemagne
Volatility in the West during the ninth and tenth centuries drove Europeans to strive for a more stable way of life. The institution of feudalism and St. Benedictââ¬â¢s monastic Rule arose in response to this problem and provided what the scattered kingdoms of the old Roman Empire were struggling to achieve. The death of Charlemagne, the succession of power to his son, Louis, and the signing of the Treaty of Verdun began the collapse of the strong and united Europe that had formerly been in place. Soon after the dissolution of the Holy Roman Empire the West started to face a myriad of problems. ââ¬Å"The renewed invasions of the Vikings, Magyars, and Muslims and the disintegration of the Carolingian Empire led to the emergence of a new type of relationship between free individualsâ⬠(Spielvogel 163). The decline in government authority and protection forced peasants, who made up the majority of the medieval population, to depend on land-owning lords and barons that acquired their properties as sovereign power decentralized. This relationship based on the context of the subjection of a subordinate to a superior became known as feudalism. Coinciding with the breakdown of government was a transformation of the Church through the way members of the religious community lived, worked, a nd worshiped. Monasticism, such as that developed by St. Benedict, formed as an answer to problems within the Church and a need for structure in religious life. St. Benedictââ¬â¢s Rule and feudalism are leading examples of how there was a resolute search for stability in medieval Europe. ââ¬Å"With the breakdown of governments, powerful nobles took control of large areas of land. They needed men to fight for them, so the practice arose of giving grants of land to vass... ... time when much of the barbarian west was only nominally Christian, Benedictââ¬â¢s Rule kept alive the spirit of pursuing a life of gospel perfectionâ⬠(Reid 50). ââ¬Å"Benedictââ¬â¢s rule, which was a synthesis of several rules, could be applied to any number of monasteries and locationsâ⬠(Vidmar 79). This universality of his rule helped to stabilize not only monasticism and the church, but also rub off on the common people and nobility that the monastics encountered. Feudalism and St. Benedictââ¬â¢s monastic rule both exemplify the search for stability in the medieval western world. Together they steadied the chaos caused by the disintegration of the Carolingian Empire and the destructive invasions of the ninth century by correcting the military, political and religious status quo. This put the West on the road to advancement, expansion, and dominance in the centuries to come.
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